San Francisco 49ers In Depth Schedule
Season: 2025-2026
| Week | Time & Day | Opponent | Opponent Head Coach | Opponent Quarterback | Stadium Type | Playing Surface |
|---|---|---|---|---|---|---|
| 1 | 4:05pm Sunday | at SEA | Mike Macdonald | N/A | Outdoor | Artificial |
| 2 | 1:00pm Sunday | at NO | Kellen Moore | N/A | Dome | Artificial |
| 3 | 4:25pm Sunday | vs ARI | Jonathan Gannon | N/A | Outdoor | Grass |
| 4 | 4:05pm Sunday | vs JAX | Liam Coen | N/A | Outdoor | Grass |
| 5 | 8:15pm Thursday | at LAR | Sean McVay | N/A | Dome | Artificial |
| 6 | 1:00pm Sunday | at TB | Todd Bowles | N/A | Outdoor | Grass |
| 7 | 8:20pm Sunday | vs ATL | Raheem Morris | N/A | Outdoor | Grass |
| 8 | 1:00pm Sunday | at HOU | DeMeco Ryans | N/A | RetractableDome | Artificial |
| 9 | 1:00pm Sunday | at NYG | Brain Daboll | N/A | Outdoor | Artificial |
| 10 | 4:25pm Sunday | vs LAR | Sean McVay | N/A | Outdoor | Grass |
| 11 | 4:05pm Sunday | at ARI | Jonathan Gannon | N/A | RetractableDome | Grass |
| 12 | 8:15pm Monday | vs CAR | Dave Canales | N/A | Outdoor | Grass |
| 13 | 1:00pm Sunday | at CLE | Kevin Stefanski | N/A | Outdoor | Grass |
| 14 | vs BYE | Outdoor | Grass | |||
| 15 | 4:25pm Sunday | vs TEN | Brian Callahan | N/A | Outdoor | Grass |
| 16 | 8:15pm Monday | at IND | Shane Steichen | N/A | RetractableDome | Artificial |
| 17 | 8:20pm Sunday | vs CHI | Ben Johnson | N/A | Outdoor | Grass |
| 18 | 12:00am Saturday | vs SEA | Mike Macdonald | N/A | Outdoor | Grass |