San Francisco 49ers In Depth Schedule
Season: 2025-2026
| Week | Time & Day | Opponent | Opponent Head Coach | Opponent Quarterback | Stadium Type | Playing Surface |
|---|---|---|---|---|---|---|
| 1 | 4:05pm Sunday | at SEA | Mike Macdonald | Sam Darnold | Outdoor | Artificial |
| 2 | 1:00pm Sunday | at NO | Kellen Moore | Tyler Shough | Dome | Artificial |
| 3 | 4:25pm Sunday | vs ARI | None | Kyler Murray | Outdoor | Grass |
| 4 | 4:05pm Sunday | vs JAX | Liam Coen | Trevor Lawrence | Outdoor | Grass |
| 5 | 8:15pm Thursday | at LAR | Sean McVay | Matthew Stafford | Dome | Artificial |
| 6 | 4:25pm Sunday | at TB | Todd Bowles | Baker Mayfield | Outdoor | Grass |
| 7 | 8:20pm Sunday | vs ATL | None | Michael Penix Jr. | Outdoor | Grass |
| 8 | 1:00pm Sunday | at HOU | DeMeco Ryans | C.J. Stroud | RetractableDome | Artificial |
| 9 | 1:00pm Sunday | at NYG | Mike Kafka (Interim) | Jaxson Dart | Outdoor | Artificial |
| 10 | 4:25pm Sunday | vs LAR | Sean McVay | Matthew Stafford | Outdoor | Grass |
| 11 | 4:05pm Sunday | at ARI | None | Kyler Murray | RetractableDome | Grass |
| 12 | 8:15pm Monday | vs CAR | Dave Canales | Bryce Young | Outdoor | Grass |
| 13 | 1:00pm Sunday | at CLE | None | Shedeur Sanders | Outdoor | Grass |
| 14 | vs BYE | Outdoor | Grass | |||
| 15 | 4:25pm Sunday | vs TEN | Mike McCoy (Interim) | Cameron Ward | Outdoor | Grass |
| 16 | 8:15pm Monday | at IND | Shane Steichen | Daniel Jones | RetractableDome | Artificial |
| 17 | 8:20pm Sunday | vs CHI | Ben Johnson | Caleb Williams | Outdoor | Grass |
| 18 | 8:00pm Saturday | vs SEA | Mike Macdonald | Sam Darnold | Outdoor | Grass |